Antigenically intact hemagglutinin in circulating avian and swine influenza viruses and potential for H3N2 pandemic
Identifieur interne : 000917 ( Main/Exploration ); précédent : 000916; suivant : 000918Antigenically intact hemagglutinin in circulating avian and swine influenza viruses and potential for H3N2 pandemic
Auteurs : Kannan Tharakaraman [États-Unis] ; Rahul Raman [États-Unis] ; Nathan W. Stebbins [États-Unis] ; Karthik Viswanathan [États-Unis] ; Viswanathan Sasisekharan [États-Unis] ; Ram Sasisekharan [États-Unis]Source :
- Scientific Reports [ 2045-2322 ] ; 2013.
Abstract
The 2009 swine-origin H1N1 influenza, though antigenically novel to the population at the time, was antigenically similar to the 1918 H1N1 pandemic influenza, and consequently was considered to be “archived” in the swine species before reemerging in humans. Given that the H3N2 is another subtype that currently circulates in the human population and is high on WHO pandemic preparedness list, we assessed the likelihood of reemergence of H3N2 from a non-human host. Using HA sequence features relevant to immune recognition, receptor binding and transmission we have identified several recent H3 strains in avian and swine that present hallmarks of a reemerging virus. IgG polyclonal raised in rabbit with recent seasonal vaccine H3 fail to recognize these swine H3 strains suggesting that existing vaccines may not be effective in protecting against these strains. Vaccine strategies can mitigate risks associated with a potential H3N2 pandemic in humans.
Url:
DOI: 10.1038/srep01822
PubMed: 23661027
PubMed Central: 3650665
Affiliations:
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Stebbins</name><affiliation wicri:level="2"><nlm:aff id="a1"><institution>Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology</institution>, 77 Massachusetts Avenue, Cambridge MA 02139</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>, 77 Massachusetts Avenue</wicri:cityArea></affiliation></author><author><name sortKey="Viswanathan, Karthik" sort="Viswanathan, Karthik" uniqKey="Viswanathan K" first="Karthik" last="Viswanathan">Karthik Viswanathan</name><affiliation wicri:level="2"><nlm:aff id="a1"><institution>Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology</institution>, 77 Massachusetts Avenue, Cambridge MA 02139</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>, 77 Massachusetts Avenue</wicri:cityArea></affiliation></author><author><name sortKey="Sasisekharan, Viswanathan" sort="Sasisekharan, Viswanathan" uniqKey="Sasisekharan V" first="Viswanathan" last="Sasisekharan">Viswanathan Sasisekharan</name><affiliation wicri:level="2"><nlm:aff id="a1"><institution>Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology</institution>, 77 Massachusetts Avenue, Cambridge MA 02139</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>, 77 Massachusetts Avenue</wicri:cityArea></affiliation></author><author><name sortKey="Sasisekharan, Ram" sort="Sasisekharan, Ram" uniqKey="Sasisekharan R" first="Ram" last="Sasisekharan">Ram Sasisekharan</name><affiliation wicri:level="2"><nlm:aff id="a1"><institution>Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology</institution>, 77 Massachusetts Avenue, Cambridge MA 02139</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>, 77 Massachusetts Avenue</wicri:cityArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The 2009 swine-origin H1N1 influenza, though antigenically novel to the population at the time, was antigenically similar to the 1918 H1N1 pandemic influenza, and consequently was considered to be “archived” in the swine species before reemerging in humans. Given that the H3N2 is another subtype that currently circulates in the human population and is high on WHO pandemic preparedness list, we assessed the likelihood of reemergence of H3N2 from a non-human host. Using HA sequence features relevant to immune recognition, receptor binding and transmission we have identified several recent H3 strains in avian and swine that present hallmarks of a reemerging virus. IgG polyclonal raised in rabbit with recent seasonal vaccine H3 fail to recognize these swine H3 strains suggesting that existing vaccines may not be effective in protecting against these strains. Vaccine strategies can mitigate risks associated with a potential H3N2 pandemic in humans.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cunha, B A" uniqKey="Cunha B">B. A. Cunha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Russell, C J" uniqKey="Russell C">C. J. 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C. de Jong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, W W" uniqKey="Thompson W">W. W. Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Igarashi, M" uniqKey="Igarashi M">M. Igarashi</name></author><author><name sortKey="Ito, K" uniqKey="Ito K">K. Ito</name></author><author><name sortKey="Kida, H" uniqKey="Kida H">H. Kida</name></author><author><name sortKey="Takada, A" uniqKey="Takada A">A. Takada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, Y P" uniqKey="Lin Y">Y. P. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Settembre, E C" uniqKey="Settembre E">E. C. Settembre</name></author><author><name sortKey="Dormitzer, P R" uniqKey="Dormitzer P">P. R. Dormitzer</name></author><author><name sortKey="Rappuoli, R" uniqKey="Rappuoli R">R. Rappuoli</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Tharakaraman, Kannan" sort="Tharakaraman, Kannan" uniqKey="Tharakaraman K" first="Kannan" last="Tharakaraman">Kannan Tharakaraman</name></region><name sortKey="Raman, Rahul" sort="Raman, Rahul" uniqKey="Raman R" first="Rahul" last="Raman">Rahul Raman</name><name sortKey="Sasisekharan, Ram" sort="Sasisekharan, Ram" uniqKey="Sasisekharan R" first="Ram" last="Sasisekharan">Ram Sasisekharan</name><name sortKey="Sasisekharan, Viswanathan" sort="Sasisekharan, Viswanathan" uniqKey="Sasisekharan V" first="Viswanathan" last="Sasisekharan">Viswanathan Sasisekharan</name><name sortKey="Stebbins, Nathan W" sort="Stebbins, Nathan W" uniqKey="Stebbins N" first="Nathan W." last="Stebbins">Nathan W. Stebbins</name><name sortKey="Viswanathan, Karthik" sort="Viswanathan, Karthik" uniqKey="Viswanathan K" first="Karthik" last="Viswanathan">Karthik Viswanathan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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